With the methods of numerical flow simulation, the global and local flow conditions and mass transport processes in a dialyzer can be analysed and based on this the clearance properties can be characterised and optimised.
The results of the simulation show how the clearance rate is influenced by the membrane properties (permeability), the fibre geometry and the flow around the hollow fibres. The model provides accurate predictions of the clearance rates of all relevant substances (urea, creatinine, vitamin B12,…). The virtual dialyzer offers the possibility of efficient dialyzer optimisation through parameter and geometry variations and allows predictions on dialysis function and haemocompatibility even before prototyping.
